abstract：PURPOSE:SUM-IAP has been developed with the aim to optimize therapeutic response and minimize toxic reactions of oxazaphosphorine cytostatics. In therapy tests in mice, the primary tumor was successfully eradicated, but animals died due to formation of lethal metastases. We supposed that high activities of SUM-IAP deto...

journal_title：Journal of cancer research and clinical oncology

authors： Voelcker G

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Cancer incidence in the elderly population has been continuously rising, and their treatment is an increasing concern among oncologists. This study aimed to evaluate the incidence and risk factors for morbidity and mortality after major oncological surgery in elderly patients with head and neck squamous cell ca...

journal_title：Journal of cancer research and clinical oncology

authors： Yoo SH,Roh JL,Choi SH,Nam SY,Kim SY

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:MicroRNAs (miRs) have been frequently reported dysregulating in tumors and playing a crucial role in tumor development and progression. However, the expression of miR-155 and its role in gastric cancer (GC) are still obscure. METHODS:qRT-PCR was applied to detect miR-155 expression in 60 matched GC samples and...

journal_title：Journal of cancer research and clinical oncology

authors： Ma Z,Ma Y,Xia Q,Li Y,Li R,Chang W,Chen J,Leng Z,Tao K

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Cluster of differentiation (CD) 44 is a cell surface receptor that correlates with the development of drug resistance in epithelial ovarian cancer (EOC). Here, we prospectively investigated the clinical impact of CD44 expression on the development of chemoresistance, and on disease-free and overall survival in ...

journal_title：Journal of cancer research and clinical oncology

authors： Elzarkaa AA,Sabaa BE,Abdelkhalik D,Mansour H,Melis M,Shaalan W,Farouk M,Malik E,Soliman AA

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:We performed deep sequencing of target genes in head and neck squamous cell carcinoma (HNSCC) tumors to identify somatic mutations that are associated with induction chemotherapy (IC) response. METHODS:Patients who were diagnosed with HNSCC were retrospectively identified. Patients who were treated with IC wer...

journal_title：Journal of cancer research and clinical oncology

authors： Ock CY,Son B,Keam B,Lee SY,Moon J,Kwak H,Kim S,Kim TM,Jeon YK,Kwon SK,Hah JH,Lee SH,Kwon TK,Kim DW,Wu HG,Sung MW,Heo DS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Mevalonate pathway inhibitors are potentially useful chemotherapeutic agents showing growth inhibition and pro-apoptotic effects in cancer cells. The effects of statins and bisphosphonates on cancer growth are attributed to a reduction in protein isoprenylation. Post-translational modification and activation of...

journal_title：Journal of cancer research and clinical oncology

authors： Garnett DJ

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Colorectal cancer (CRC) is one of the major health problems worldwide and is often diagnosed at late stage. There is growing body of evidence in early detection of this disease with novel screening modalities to reduce compliance and increase specificity of available methods. The aim of current review is to giv...

journal_title：Journal of cancer research and clinical oncology

authors： Vatandoost N,Ghanbari J,Mojaver M,Avan A,Ghayour-Mobarhan M,Nedaeinia R,Salehi R

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Oral cancer (OC) patients are at high risk to develop recurrent disease or secondary primary cancers with no available biomarkers to detect these events until a visible lesion is readily present and diagnosed by biopsy. Exosomes secreted by cancer cells are involved in tumor growth, invasion and metastasis. We ...

journal_title：Journal of cancer research and clinical oncology

authors： Zlotogorski-Hurvitz A,Dayan D,Chaushu G,Salo T,Vered M

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To identify crucial molecular alterations of receptor tyrosine kinases that can be used as potential therapeutic targets for eyelid sebaceous gland carcinoma (SbGC). METHODS:The expression levels of HER2, EGFR, C-MET, and FGFR1 were determined by immunohistochemistry (IHC). The copy numbers of the HER2, EGFR, ...

journal_title：Journal of cancer research and clinical oncology

authors： Lee MJ,Kim N,Choung HK,Choe JY,Khwarg SI,Kim JE

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether an association exists between a history of fertility treatments and future risk of female malignancies. STUDY DESIGN:A population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of fertility treatments including in vit...

journal_title：Journal of cancer research and clinical oncology

authors： Kessous R,Davidson E,Meirovitz M,Sergienko R,Sheiner E

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Abnormal expression of miRNAs is intimately related to a variety of human cancers. The purpose of this study is to confirm the expression of miR-181a and elucidate its physiological function and mechanism in pediatric acute myeloid leukemia (AML). METHODS:Pediatric AML patients and healthy controls were enroll...

journal_title：Journal of cancer research and clinical oncology

authors： Liu X,Liao W,Peng H,Luo X,Luo Z,Jiang H,Xu L

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Riproximin, a type II ribosome-inactivating protein (RIP), has shown significant cytotoxic effects in diverse types of cancer cells. To better understand its therapeutic potential, elaborated investigations on the mechanistic aspects of riproximin deem crucial. In this study, we focused on riproximin-mediate...

journal_title：Journal of cancer research and clinical oncology

authors： Pervaiz A,Zepp M,Adwan H,Berger MR

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Allogeneic haematopoietic stem cell transplantation (HSCT) is a proven treatment for patients with haematological malignancies. In this retrospective analysis, the impact of donor matching on outcome of unrelated HSCT was analysed in patients transplanted at the University of Leipzig. METHODS:From 2000 to 2009...

journal_title：Journal of cancer research and clinical oncology

authors： Rockstroh A,Al-Ali HK,Lange T,Pönisch W,Krahl R,Cross M,Behre G,Niederwieser D,Pfrepper C

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Lung cancer has become a crucial problem among individuals living with the human immunodeficiency virus (HIV) and causes high mortality in Western countries. Japan has an increasing number of newly infected HIV patients, and lung cancer is becoming a theme in this population. However, clinical factors of this p...

journal_title：Journal of cancer research and clinical oncology

authors： Okuma Y,Tanuma J,Kamiryo H,Kojima Y,Yotsumoto M,Ajisawa A,Uehira T,Nagai H,Takeda Y,Setoguchi Y,Okada S

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:In 2008, we reported that 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (GTE), reduced the recurrence of colorectal adenoma by 51.6% in patients after polypectomy. Based on these results, we paid special attention to Japanese cancer patients, who consume green tea ever...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Sueoka E,Watanabe T,Suganuma M

更新日期：2015-09-01 00:00:00

abstract：PURPOSES:Genetic variations among prostate cancer patients who underwent radical prostatectomies were evaluated to predict biochemical recurrence, and used to develop a clinical-genetic model that combines data on clinicopathological factors of prostate cancer and individual genetic variations. MATERIALS AND METHODS:W...

journal_title：Journal of cancer research and clinical oncology

authors： Oh JJ,Park S,Lee SE,Hong SK,Lee S,Lee HM,Lee JK,Ho JN,Yoon S,Byun SS

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:The aim of our study was to identify factors which influence survival in patients with disseminated seminoma in the good prognostic group according to IGCCCG, as well as to evaluate the impact of treatment intensification in patients with negative prognostic factors. METHODS:We analyzed the database of the pat...

journal_title：Journal of cancer research and clinical oncology

authors： Fedyanin M,Tryakin A,Bulanov A,Vybarava A,Tjulandina A,Chekini D,Sekhina O,Figurin K,Garin A,Tjulandin S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Acute intestinal damage induced by chemotherapeutic agent is often a dose-limiting factor in clinical cancer therapy. The aim of this study was to investigate the effect of chemokine CXCL9 on the intestinal damage after chemotherapy and explore the therapeutic potential of anti-CXCL9 agents. METHODS:In vitro c...

journal_title：Journal of cancer research and clinical oncology

authors： Lu H,Liu H,Wang J,Shen J,Weng S,Han L,Sun T,Qian L,Wu M,Zhu S,Yu Y,Han W,Zhu J,Moldenhauer A

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The TNM classification is used to assess cancers of the oral cavity, and advancements in imaging techniques have revealed clear variations in tumor volume at presentation. This study therefore aimed to clarify whether preoperative imaging, with exact measurements of the tumor, could affect post-surgery survival...

journal_title：Journal of cancer research and clinical oncology

authors： Mücke T,Mitchell DA,Ritschl LM,Tannapfel A,Wolff KD,Kesting MR,Loeffelbein DJ,Kanatas A

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Tobacco exposure remains the main etiologic factor for lung cancer (LC). Interactions between environment and individual genetic profile are particularly important for this disease. The aim of this study was to evaluate the contribution of CYP1A1*2A, CYP1A1*2C, CYP2D6*4, GSTP1, GSTM1, GSTT1 and NAT2 polymorp...

journal_title：Journal of cancer research and clinical oncology

authors： Mota P,Silva HC,Soares MJ,Pego A,Loureiro M,Cordeiro CR,Regateiro FJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:PTEN is an essential tumour suppressor gene which encodes a phosphatase protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this tumour suppressor pathway potentially becomes a causal factor for development of malignancies. This review aims to assess current understanding of mechanis...

journal_title：Journal of cancer research and clinical oncology

authors： Lim HJ,Crowe P,Yang JL

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The optimal interval between neoadjuvant chemoradiotherapy (CRT) and surgery has yet to be established. Additionally, it is unknown whether patients with different pathologic stages or chemoradiation responses should undergo different intervals between CRT and surgery. Therefore, the purpose of this study wa...

journal_title：Journal of cancer research and clinical oncology

authors： You KY,Huang R,Zhang LN,Ding PR,Xiao WW,Qiu B,Chang H,Zeng ZF,Pan ZZ,Gao YH

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in gastric cancer patients. METHODS:A systematic literature search was conducted to identify eligible studies in PubMed and Embase. The pooled hazard ratios (HRs) or odds ratios (ORs) with their correspond...

journal_title：Journal of cancer research and clinical oncology

authors： Wei K,Jiang L,Wei Y,Wang Y,Qian X,Dai Q,Guan Q

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Alzheimer disease (AD) and cancer are seemingly two opposite ends of one spectrum. Studies have suggested that patients with AD showed a reduced risk of cancer and vice versa. However, available evidences are not conclusive. So we conducted a meta-analysis using published literatures to systematically examine c...

journal_title：Journal of cancer research and clinical oncology

authors： Shi HB,Tang B,Liu YW,Wang XF,Chen GJ

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Significant prolongation of overall survival (OS) has been reached in metastatic colorectal cancer (mCRC) treatment within the last 5-10 years. Our study was conducted in order to evaluate and compare OS of different standard of care treatment options in a university-based outpatient clinic. METHODS:One hundre...

journal_title：Journal of cancer research and clinical oncology

authors： Moehler M,Thomaidis T,Zeifri C,Barhoom T,Marquardt J,Ploch P,Schattenberg J,Maderer A,Schimanski CC,Weinmann A,Woerns MA,Kranich AL,Warnecke JM,Galle PR

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Pancreatic cancer is commonly detected at advanced stages when the tumor is no longer amenable to surgical resection. Therefore, finding biomarkers for early stage disease is urgent. Here, we show that high-definition mass spectrometry (HDMS(E)) can be used to identify serum protein alterations associated with ...

journal_title：Journal of cancer research and clinical oncology

authors： Ansari D,Andersson R,Bauden MP,Andersson B,Connolly JB,Welinder C,Sasor A,Marko-Varga G

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Lysine-specific demethylase 1 (LSD1) was highly expressed in several malignancies and had been implicated in pathological processes of cancer cells. However, the role of LSD1 in colorectal cancer (CRC) carcinogenesis, prognosis and treatment remains uncharacterized. METHODS:In this study, we examined LSD1 expr...

journal_title：Journal of cancer research and clinical oncology

authors： Hsu HC,Liu YS,Tseng KC,Yang TS,Yeh CY,You JF,Hung HY,Chen SJ,Chen HC

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Signalling through the insulin-like growth factor 1 receptor (IGF-1R) is implicated in carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. The purpose of this study was to investigate the prognostic role of IGF-1R expression in surgically resected non-small-cell lung cancer (NSCLC), and re...

journal_title：Journal of cancer research and clinical oncology

authors： Agulló-Ortuño MT,Díaz-García CV,Agudo-López A,Pérez C,Cortijo A,Paz-Ares L,López-Ríos F,Pozo F,de Castro J,Cortés-Funes H,López Martín JA

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Non-adherence to anti-hormonal therapy is a major problem in gynecologic oncology. Reasons reported are side effects and lack of support. The aim of our study was an analysis of influence of experiences of patients with endocrine therapy and communication and information on this topic and their influence o...

journal_title：Journal of cancer research and clinical oncology

authors： Wuensch P,Hahne A,Haidinger R,Meißler K,Tenter B,Stoll C,Senf B,Huebner J

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to summarize the accuracy of preoperative vascular invasion with endoscopic ultrasound (EUS) and computed tomography (CT) test performance in pancreatic cancer with meta-analysis METHOD:Two reviewers searched MEDLINE database to identify relevant studies. The reference lists o...

journal_title：Journal of cancer research and clinical oncology

authors： Yang R,Lu M,Qian X,Chen J,Li L,Wang J,Zhang Y

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Piperlongumine (PL) has been shown to selectively induce apoptotic cell death in cancer cells via reactive oxygen species (ROS) accumulation. In this study, we characterized a molecular mechanism for PL-induced cell death. METHODS:Cell viability and cell death were assessed by MTT assay and Annexin V-FITC/PI s...

journal_title：Journal of cancer research and clinical oncology

authors： Jin HO,Lee YH,Park JA,Lee HN,Kim JH,Kim JY,Kim B,Hong SE,Kim HA,Kim EK,Noh WC,Kim JI,Chang YH,Hong SI,Hong YJ,Park IC,Lee JK

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:In 2013, 2009, and 2006, the Arbeitsgemeinschaft Gynäkologische Onkologie evaluated the therapeutic approaches and the adherence to their guidelines for endometrial carcinoma (EC) in Germany. Here, we present the results concerning the surgical procedures. METHODS:A questionnaire was developed and sent to 682 ...

journal_title：Journal of cancer research and clinical oncology

authors： Battista MJ,Schmidt M,Rieks N,Steetskamp J,Sicking I,Lebrecht A,Koelbl H,Mallmann P,Hoffmann G,Steiner E

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of p...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang ZM,Wang Y,Huang R,Liu YP,Li X,Hu FL,Zhu L,Wang F,Cui BB,Dong XS,Zhao YS

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and adolescents. However, few biomarkers of diagnostic significance have been established. In recent years, high-throughput transcriptomic and metabolomic approaches make it possible for studying the levels of thousands of bioma...

journal_title：Journal of cancer research and clinical oncology

authors： Chen K,Zhu C,Cai M,Fu D,Cheng B,Cai Z,Li G,Liu J

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Treatment for malignant ascites in advanced ovarian cancer (OC) patients remains controversial. The objective of this study was to investigate the efficacy of combined continuous circulatory hyperthermic intraperitoneal chemotherapy (HIPEC) preceded or followed by cytoreductive surgery (CRS) f...

journal_title：Journal of cancer research and clinical oncology

authors： Ba M,Long H,Zhang X,Tang Y,Wu Y,Yu F,Wang S,Cui S

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) sometimes presents with an indolent course without any significant symptoms. Here, the potential impact of active surveillance (AS) on clinical outcomes in asymptomatic or minimally symptomatic mRCC patients was retrospectively evaluated. METHODS:mRCC patients who were fo...

journal_title：Journal of cancer research and clinical oncology

authors： Park I,Lee JL,Ahn JH,Lee DH,Lee KH,Jeong IG,Song C,Hong B,Hong JH,Ahn H

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:The present study was designed to investigate the possible protective effects of berberine against cyclophosphamide (CP)-induced hepatotoxicity in rats. METHODS:The experimental rats were treated with berberine orally at a dose of 50 mg/kg for 11 consecutive days after the administration of a single intrape...

journal_title：Journal of cancer research and clinical oncology

authors： Germoush MO,Mahmoud AM

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:A high proportion of cancer patients use complementary and alternative medicine (CAM). In oncology, risks of CAM are side effects and interactions. OBJECTIVE:Our aim was to conduct a survey on professionals in palliative care regarding attitudes toward CAM. DESIGN AND SUBJECTS:An internet-based survey with...

journal_title：Journal of cancer research and clinical oncology

authors： Conrad AC,Muenstedt K,Micke O,Prott FJ,Muecke R,Huebner J

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:A number of studies have investigated the role of serum lactate dehydrogenase (LDH) level in patients with osteosarcoma but have yielded inconsistent and inconclusive results. Thus, we conducted a meta-analysis to assess its prognostic value more precisely. METHODS:Systematic computerized searches of PubMed...

journal_title：Journal of cancer research and clinical oncology

authors： Chen J,Sun MX,Hua YQ,Cai ZD

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:To analyze prognostic factors and long-term outcomes in patients with locally recurrent pelvic cancer (LRPC) treated with a multidisciplinary approach. METHODS AND MATERIALS:From January 1995 to December 2011, 81 patients [rectal (47 %); gynecologic (39 %); retroperitoneal sarcoma (14 %)] underwent extended su...

journal_title：Journal of cancer research and clinical oncology

authors： Sole CV,Calvo FA,de Sierra PA,Herranz R,Gonzalez-Bayon L,García-Sabrido JL

更新日期：2014-07-01 00:00:00